RANGAP1 polyclonal antibody
产品名称： RANGAP1 polyclonal antibody
英文名称： RANGAP1 polyclonal antibody
产品编号： PAB6571
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of RANGAP1.
- Immunogen:
- A synthetic peptide corresponding to human RANGAP1.
- Sequence:
- ASEDIAKLAETLAK-C
- Host:
- Goat
- Theoretical MW (kDa):
- 63.5
- Reactivity:
- Human, Mouse
- Specificity:
- In mouse, there is a hypothetical protein called "similar to RANGAP1" (XP_139737.2) that is virtually identical.
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:32000)
Western blot (0.1-0.5 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.
Bischoff FR, Krebber H, Kempf T, Hermes I, Ponstingl H.Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1749-53.
- Applications
- Western Blot (Cell lysate)
- RANGAP1 polyclonal antibody (Cat # PAB6571) staining (0.2 ug/mL) of NIH/3T3 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
- Entrez GeneID:
- 5905
- Protein Accession#:
- NP_002874
- Gene Name:
- RANGAP1
- Gene Alias:
- Fug1,KIAA1835,MGC20266,SD
- Gene Description:
- Ran GTPase activating protein 1
- Omim ID:
- 602362
- Gene Ontology:
- Hyperlink
- Gene Summary:
- RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq
- Other Designations:
- OTTHUMP00000028918,segregation distorter homolog,segregation distortion